Thyroid EIA-TG Test Kit

Thyroid EIA-TG Test Kit
Thyroid EIA-TG Test Kit
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Product Code : 100-29
Brand Name : Alkor Bio
Product Description
Thyroglubulin (TG) is the main protein produced by thyroid gland. It is the precursor and the deposit form of thyroid hormones thyroxin (T4) and triiodothyronine (T3).TG is an iodinated glycoprotein with a molecular weight of 660 KDa that consists of two subunits. TG concentration in serum depends on mass of thyroid gland, its functional status and degree of inflammation. In healthy people TG concentration varies from 2 to 50 ng/ml and may increase about twofold during the pregnancy. After surgical operation or treatment with radioactive iodine TG concentration remains increased for several weeks. In the population suff ering from environmental iodine deficiency mean TG concentration in blood is increased. Since 1994 TG has been regarded by WHO as one of the indicators of endemic goiter.

Serum TG measurement is performed mostly for monitoring of thyroid carcinoma patients. Dynamics of TG concentration is used as a marker for evaluation of treatment efficiency, revealing of possible recurrence and metastases in patients after thyrectomia. This parameter is not used for primary diagnostics of thyroid cancer. TG concentration in serum may be useful for exact diagnostics in the case of congenital hypothyrosis. Increased TG concentration permits to differentiate subacute thyroiditis from pharmacological thyrotoxicosis (when TG level remains stable). In patients with Grave’s disease increase in TG concentration is a preliminary sign of recurrency after canceling of suppressive therapy.

TG measurement may be affected by presence of anti-TG autoantibodies in the serum sample. In this case the results may be false-negative. To obtain the reliable results it is recommended always to combine TG and anti-TG autoantibodies determination. Serial TG determinations for patient monitoring should be always done by the same method. The physician should be always informed not only of the results of TG determination but also of the type of assay used. When the type of diagnostic kit is changed, the laboratory must perform the appropriate clinical evaluation and compare the range of the results obtained with two types of kits.

ThyroidEIA-TG kit is intended for the quantitative determination of thyroglobulin in human serum.


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