Autoimmune antibodies against thyroid peroxidase (Anti-TPO) are mainly IgG and, in less extent, IgM. TPO is a key enzyme in the biosynthesis of thyroid hormones. In healthy individuals, concentrations of Anti-TPO in serum may reach 30 U/ml.
Quantitatively, exceeding this limit is the sign of an autoimmune process that usually leads to thyroid dysfunction, mainly due to reduced thyroxin secretion. Quantitative determination of Anti-TPO antibodies in erum is used for diagnosis of autoimmune thyroid diseases, such as idiopathic myxoedema, Hashimotoâs thyroiditis and Gravesâs syndrome.
ThyroidEIA-Anti-TPO kit is intended for the quantitative determination of autoimmune antibodies against thyroid peroxidase in human serum.