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A significant amount of women (about 10-20%), if not subjected to vaccination, will reach fertile age without having acquired immunity against the Rubella virus. The diagnosis of Rubella infection in its acute stage is therefore particularly important in pregnant women. It is usually performed by testing for the presence of IgM antibodies. Identifying the acute phase of the disease, based upon a single sample however may turn out difficult, either due to IgM persistence (often protracted) or else to the presence of IgM in cases of asymptomatic Rubella infection, which is not threatening for the fetus. Measuring the avidity of specific IgG was demonstrated to be particularly useful in identifying primary infection. As a matter of fact, the initial IgG antibody response to infection is characterized by antibodies with low avidity, in which binding to the specific antigen sites is easily dissociated.
Rubella IgG Avidity kit is designed for determination of IgG antibodies avidity for Rubella virus in human serum or plasma by enzyme immunoassay method – ELISA (Sandwich assay).